About SeDia

Study Objectives

1. To determine the incidence rate and the risk factors (sociodemographic, dietary, psychosocial, biological such as genomics/genetics, glycoproteomics, metabolomics, proteomics, lipidomics, cytokines and adipokines, hormonal, biochemical) and their interaction for:

  1. the development and progression of renal impairment and chronic renal failure
  2. the development and progression of diabetic retinopathy
  3. the development of angina pectoris and myocardial infarction
  4. the development of transient ischaemic attack and stroke
  5. the development of limb gangrene
  6. the development of diabetic neuropathy
  7. hospitalisation and mortality

2. To determine the incidence rates and risk factors (sociodemographic, dietary, psychosocial, biological such as genomics/genetics, glycoproteomics, metabolomics, proteomics, lipidomics, cytokines and adipokines, hormonal, biochemical) and their interaction for:

  1. the development and progression of insulin resistance
  2. the development and progression of impaired glucose tolerance
  3. the development and progression of diabetes

3. To determine the incidence rate and risk factors for the development of diabetes in household family membersof diabetic patients.

  1. the development and progression of insulin resistance
  2. the development and progression of impaired glucose tolerance
  3. the development and progression of diabetes

4. To develop:

  1. predictive biomarkers
  2. statistical models and algorithms
  3. diabetes complications risk score for patients with diabetes and their household family members

SeDia Cohort is established, maintained and governed as a collaborative public-private partnership between the Ministry of Health (MOH), Malaysia and the International Medical University (IMU), Kuala Lumpur. The MOH will be represented by Negeri Sembilan Health Department and Seremban District Health Office.